The new Grand Challenge projects are starting
CSC has approved four projects from the 2013 Grand Challenge call. Grand Challenge projects are aimed at high-impact scientific research that requires computational or data resources exceeding CSC’s standard project quotas or level of services. CSC allocates a support group for each GC project.
Ilpo Vattulainen: Interactions of cholesterol with GPCRs (Tampere University of Technology)
The objective of this project is to understand how cholesterol modulates the structure (conformation) and function of human beta-2-adrenergic (beta2AR) receptors. Beta2ARs have been studied extensively as drug targets due to their relationship to, e.g., asthma and heart failure. These proteins belong to a superfamily of G-protein coupled receptors (GPCRs). GPCRs form the largest group of integral membrane proteins with a great importance in signal transduction, thereby making them an ideal target for drug design. In addition to currently being one of the hottest topics in biomedical sciences, GPCRs have also gained public attention due to the 2012 Nobel Prize in Chemistry, which was awarded to the two pioneering scientists in the field, Brian Kobilka and Robert Lefkowitz. The project will onsume 10 000 000 CPU hours.