Developed Technologies and Services

Several technologies and services are available for out-licencing and further joint development with industrial partners.

CellVisus

CellVisus is a novel service for quantifying cardiomyocyte biomechanics. We can analyze the contraction activity of cardiac cells from microscopy videos and provide result reports with parameters characterizing the beating behavior. CellVisus can be used in various studies, such as screening or characterization studies, in both augmenting and standalone roles.

More information: CellVisus website

Vasculogenesis-Angiogenesis Model

For investigating inhibitors of blood vessel formation. Human cell-based 3D-model of vashculogenesis-angiogenesis structure. End points: a) Tubule length and number of  branches, b) Cytotoxicity. Validated per OECD GD 34. Testing service is readily available.

More information: Vasculogenesis-Angiogenesis Model brochure (pdf)

PermeaSys

A novel approach to study penetration of drug molecules through various membranes, including cultivated cell membranes, ex vivo membranes and tissues, biopsy samples, artificial membranes etc. The devise is based on microfluidistics, which provides several advantages. Concentrations of test substance at donor chamber can be low i.e. close to physiological concentrations and consumption of test compound(s) is minimal. In addition, toxic effects of your test compound can be tested with targeted membranes. The device can also be used as dynamic platform for cell culture based test models.

More information: PermeaSys brochure (pdf)

Ocular Surface Biomarker Panel

Tear protein-based multi-marker panel for detection of ocular surface condition. Panel consisting of 60 known and novel tear proteins (biomarkers). Biomarkers are related to inflammation, apoptosis, wound healing, angiogenesis, cell proliferation and migration, lacrimal gland secretion. Finding the right treatment for each patient.

In vitro Neurotest platform

Neuro-test chamber is intended for various types of neuro research in vitro. By the aid of the device one can detect growth of individual axons and also formation of myelin tube if desired. It is  also possible  follow and document effects of toxic chemicals as well as drug molecules to the well being of neurons/axons and myelin tube. The processes can be detected both by means of imaging and electronic measurements.

More information: In vitro Neurotest platform brochure (pdf)

Treatment for corneal limbal stem cell deficiency

Cornea epithelial limbal stem cells are essential for maintaining wellbeing and clarity of the cornea. In case of losing the limbal stem cells there is a high likelihood of losing one’s vision too. The therapy under development is the first valid therapy for patients missing limbal corneal stem cells in both eyes. Availability of limbal corneal stem cells in treatment of serious corneal damages can be secured by recovering the limbal stem cell function in the damaged eyes.

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